Neuropsychological deficits in long-term frequent cannabis users

Neurology. 2006 Mar 14;66(5):737-9. doi: 10.1212/01.wnl.0000201279.83203.c6.


The authors examined neuropsychological functioning in 20 long-term (LT), 20 shorter term (ST) heavy frequent cannabis users, and 24 controls after abstinence for > or =24 hours prior to testing. LT users performed significantly worse on verbal memory and psychomotor speed. LT and ST users had a higher proportion of deficits on verbal fluency, verbal memory, attention, and psychomotor speed. Specific cognitive domains appear to deteriorate with increasing years of heavy frequent cannabis use.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Attention
  • Attention Deficit Disorder with Hyperactivity / etiology
  • Female
  • Humans
  • Male
  • Marijuana Abuse / physiopathology*
  • Marijuana Abuse / psychology*
  • Memory / physiology*
  • Memory Disorders / etiology*
  • Middle Aged
  • Motor Activity / physiology*
  • Reference Values
  • Speech*
  • Time Factors