Higher platelet P-selectin in male patients with inflammatory bowel disease compared to healthy males

World J Gastroenterol. 2006 Feb 28;12(8):1270-2. doi: 10.3748/wjg.v12.i8.1270.

Abstract

Aim: To observe if the total amount of platelet P-selectin (tP-selectin) in patients with inflammatory bowel disease (IBD) was related to disease entity or activity, 5-aminosalicylic acid (5-ASA) medication or gender.

Methods: tP-selectin was measured by immunoassay in seventeen IBD patients and twelve healthy controls.

Results: Compared to controls, there was no difference of tP-selectin in patients related to disease entity or activity and 5-ASA medication. When the groups were split according to gender the male patient group showed higher levels of tP-selectin compared to male controls (153 ng/mL vs 94 ng/mL, P<0.05).

Conclusion: Increased tP-selectin levels may alter the inflammatory response and susceptibility to thromboembolic disease. As previously shown with soluble P-selectin, tP-selectin shows gender dependent differences important to consider in future studies.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Blood Platelets / chemistry*
  • Colitis, Ulcerative / blood*
  • Colitis, Ulcerative / drug therapy
  • Colitis, Ulcerative / physiopathology
  • Crohn Disease / blood*
  • Crohn Disease / drug therapy
  • Crohn Disease / physiopathology
  • Disease Progression
  • Disease Susceptibility
  • Female
  • Humans
  • Male
  • Mesalamine / therapeutic use
  • Middle Aged
  • P-Selectin / blood*
  • Risk Factors
  • Sex Characteristics*
  • Thromboembolism / epidemiology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • P-Selectin
  • Mesalamine