Abstract
The maleless (mle) gene is one of four known regulatory loci required for increased transcription (dosage compensation) of X-linked genes in D. melanogaster males. A predicted mle protein (MLE) contains seven short segments that define a superfamily of known and putative RNA and DNA helicases. MLE, while present in the nuclei of both male and female cells, differs in its association with polytene X chromosomes in the two sexes. MLE is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females. The predominant localization of MLE to the X chromosome in males makes it a strong candidate to be a direct regulator of dosage compensation.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Blotting, Western
-
Cell Compartmentation
-
Chromosomal Proteins, Non-Histone*
-
Chromosome Mapping
-
Cloning, Molecular
-
DNA Helicases / genetics
-
DNA Helicases / immunology
-
DNA Helicases / metabolism
-
DNA-Binding Proteins*
-
Dosage Compensation, Genetic*
-
Drosophila Proteins*
-
Drosophila melanogaster / genetics*
-
Female
-
Fluorescent Antibody Technique
-
Gene Expression Regulation
-
Genes, Regulator*
-
Insect Hormones / genetics*
-
Insect Hormones / immunology
-
Insect Hormones / metabolism
-
Male
-
Molecular Sequence Data
-
Nuclear Proteins / genetics*
-
Nuclear Proteins / immunology
-
Nuclear Proteins / metabolism
-
RNA, Messenger / genetics
-
Transcription Factors / genetics*
-
Transcription Factors / immunology
-
Transcription Factors / metabolism
-
Transcription, Genetic
-
X Chromosome
Substances
-
Chromosomal Proteins, Non-Histone
-
DNA-Binding Proteins
-
Drosophila Proteins
-
Insect Hormones
-
Nuclear Proteins
-
RNA, Messenger
-
Transcription Factors
-
mle protein, Drosophila
-
DNA Helicases
Associated data
-
GENBANK/M60962
-
GENBANK/M64383
-
GENBANK/M64384
-
GENBANK/M74121
-
GENBANK/S44821
-
GENBANK/S54711
-
GENBANK/S55195
-
GENBANK/S55197
-
GENBANK/S56137
-
GENBANK/S56139