Cyclic nucleotide-dependent protein kinases

Pharmacol Ther. 1991;50(1):123-45. doi: 10.1016/0163-7258(91)90075-w.


The actions of several hormones and neurotransmitters evoke signal transduction pathways which rapidly elevate the cytosolic concentrations of the intracellular messengers, cAMP and cGMP. The cyclic-nucleotide dependent protein kinases, cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG), are the major intracellular receptors of cAMP and cGMP. These enzymes become active upon binding respective cyclic nucleotides and modulate a diverse array of biochemical events through the phosphorylation of specific substrate proteins. The focus of this review is to describe the progress made in understanding the structure and function of both PKA and PKG.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Cyclic AMP / metabolism*
  • Cyclic GMP / metabolism*
  • Enzyme Activation
  • Phosphorylation
  • Protein Kinases / metabolism
  • Protein Kinases / physiology*
  • Signal Transduction / physiology
  • Substrate Specificity


  • Cyclic AMP
  • Protein Kinases
  • Cyclic GMP