New insights into and novel applications for platelet-rich fibrin therapies

Trends Biotechnol. 2006 May;24(5):227-34. doi: 10.1016/j.tibtech.2006.02.010. Epub 2006 Mar 15.


The therapeutic use of autologous platelet-rich plasma constitutes a relatively new biotechnology that has been a breakthrough in the stimulation and acceleration of soft-tissue and bone healing. The efficiency of this process lies in the local and continuous delivery of a wide range of growth factors and proteins, mimicking the needs of the physiological wound healing and reparative tissue processes. Consequently, the application of platelet-rich plasma has been extended to many different fields, including orthopedics, sports medicine, dentistry, cosmetic and periodontal medicine and cosmetic, plastic and maxillofacial surgery. This article highlights the use of this technology and discusses some of the obstacles and challenges that need to be addressed to maintain progress in this field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Platelets*
  • Fibrin / therapeutic use*
  • Fractures, Bone / therapy*
  • Humans
  • Musculoskeletal Diseases / therapy*
  • Platelet Transfusion / methods*
  • Platelet Transfusion / trends
  • Soft Tissue Injuries / therapy*
  • Tissue Engineering / methods*
  • Tissue Engineering / trends


  • Fibrin