Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population

J Neurogenet. Jul-Dec 2005;19(3-4):155-61. doi: 10.1080/01677060600569721.

Abstract

Recently, the involvement of the inflammatory response in Alzheimer's disease (AD) has received considerable attention. The gene encoding for interleukin-6 (IL-6) is interesting since IL-6 has been reported not only to be involved in immune functions but also in AD. We investigated whether the IL-6-174 G/C polymorphism is associated with late onset AD (LOAD) in the Finnish subjects. The G allele was over-represented in ApoE4-LOAD patients but remained unimportant in all and in the ApoE E4 carriers. Interestingly, the G allele frequency was lower in our population in both AD patients and in controls compared to Southern European populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / genetics*
  • Apolipoprotein E4
  • Apolipoproteins E / genetics
  • Female
  • Finland
  • Gene Frequency / genetics
  • Humans
  • Interleukin-6 / genetics*
  • Male
  • Polymorphism, Genetic / genetics*
  • Promoter Regions, Genetic / genetics*

Substances

  • Apolipoprotein E4
  • Apolipoproteins E
  • Interleukin-6