Phosphorylation of transcriptional factors and cell-cycle-dependent proteins by casein kinase II

Curr Opin Cell Biol. 1991 Jun;3(3):474-83. doi: 10.1016/0955-0674(91)90076-b.


Casein kinase II is involved in the phosphorylation of several proto-oncogenes, anti-oncogenes, and oncogenes that are nuclear transcriptional regulatory factors. The potential functions of the phosphorylations in each of these proteins are evaluated. New findings indicate that casein kinase II is a critical component of the mechanisms regulating the cell cycle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenovirus Early Proteins
  • Amino Acid Sequence
  • Animals
  • Antigens, Polyomavirus Transforming / metabolism
  • Casein Kinases
  • Cell Cycle / physiology*
  • Cell Division
  • Humans
  • Molecular Sequence Data
  • Oncogene Proteins, Viral / metabolism
  • Phosphorylation
  • Protein Kinases / metabolism*
  • Protein-Tyrosine Kinases / metabolism
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-myb
  • Receptors, Thyroid Hormone
  • Substrate Specificity
  • Transcription Factors / metabolism*


  • Adenovirus Early Proteins
  • Antigens, Polyomavirus Transforming
  • Oncogene Proteins, Viral
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-myb
  • Receptors, Thyroid Hormone
  • Transcription Factors
  • Protein Kinases
  • Protein-Tyrosine Kinases
  • Casein Kinases