BRCA1-positive breast cancers in young women from Poland

Breast Cancer Res Treat. 2006 Sep;99(1):71-6. doi: 10.1007/s10549-006-9182-3. Epub 2006 Mar 16.


We identified 4316 unselected incident cases of early-onset breast cancers (<51 ears of age at diagnosis) in 18 Polish hospitals between 1996 and 2003. We were able to obtain a blood sample for DNA analysis from 3472 of these (80.4%). All cases were tested for the presence of three founder mutations in BRCA1. The proportion of cases with a BRCA1 mutation was 5.7%. The hereditary proportions were higher than this for women with breast cancer diagnosed before age 40 (9%), for women with cancer of medullary or atypical medullary histology (28%), for those with bilateral cancer (29%) or with a family history of breast or ovarian cancer (13%). It is reasonable to offer genetic testing to women with early-onset breast cancer in Poland.

MeSH terms

  • Adult
  • BRCA1 Protein / biosynthesis*
  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism
  • DNA Mutational Analysis
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Genes, BRCA1*
  • Genetic Predisposition to Disease*
  • Humans
  • Middle Aged
  • Models, Statistical
  • Mutation*
  • Poland
  • Prospective Studies


  • BRCA1 Protein