Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke

Neuropediatrics. 2006 Feb;37(1):46-52. doi: 10.1055/s-2006-923934.


We used verb generation and story listening tasks during fMRI to study language organization in children (7, 9 and 12 years old) with perinatal left MCA infarctions. Healthy, age-matched comparison children (n = 39) showed activation in left Broca's area during the verb generation task; in contrast, stroke subjects showed activation either bilaterally or in the right hemisphere homologue during both tasks. In Wernicke's area, comparison subjects showed left lateralization (verb generation) and bilateral activation (L > R) (story listening). Stroke subjects instead showed bilateral or right lateralization (verb generation) and bilateral activation (R > L) (story listening). Language is distributed atypically in children with perinatal left hemisphere stroke.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Mapping
  • Case-Control Studies
  • Child
  • Female
  • Frontal Lobe / blood supply*
  • Frontal Lobe / physiopathology
  • Functional Laterality
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Infarction, Middle Cerebral Artery / physiopathology*
  • Language*
  • Magnetic Resonance Imaging*
  • Male
  • Neuropsychological Tests / statistics & numerical data
  • Oxygen / blood
  • Time Factors
  • Verbal Behavior / physiology*


  • Oxygen