ProFit: two-dimensional prior-knowledge fitting of J-resolved spectra

NMR Biomed. 2006 Apr;19(2):255-63. doi: 10.1002/nbm.1026.


A two-dimensional fitting procedure is introduced, capable of extracting the full amount of information from 2D J-resolved magnetic resonance spectroscopic data. The fitting procedure uses a linear combination of 2D model spectra. For reducing the degrees of freedom and increasing robustness, it is divided into a non-linear outer loop and an inner linear least-squares fit for the concentrations. In vitro and in vivo experiments on a whole-body 3 T MR scanner show the detectability of a wide range of metabolites in the human brain, namely total creatine, N-acetylaspartate, N-acetylaspartylglutamate, choline-containing compounds, glutamate, myo-inositol, glutathione, scyllo-inositol, gamma-aminobutyric acid, alanine and ascorbic acid.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algorithms*
  • Creatine / metabolism*
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Nerve Tissue Proteins / metabolism*
  • Neurotransmitter Agents / metabolism*
  • Parietal Lobe / metabolism*
  • Spectrum Analysis / methods
  • Tissue Distribution


  • Nerve Tissue Proteins
  • Neurotransmitter Agents
  • Creatine