Active Human herpesvirus-6 (HHV-6) Infection Associated With Kikuchi-Fujimoto Disease and Systemic Lupus Erythematosus (SLE)

In Vivo. May-Jun 1991;5(3):265-9.


Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) is a well defined disorder primarily affecting young adults. The cause of this disease is still unknown. The authors report a case of a 37-yar old woman with Kikuchi-Fujimoto disease and systemic lupus erythematosus (SLE). Serologic testing for HHV-6 antibodies revealed an active infection. An excised cervical lymph node contained HHV-6 genome demonstrated by using in situ hybridization. Active HHV-6 infection should be considered in Kikuchi-Fujimoto disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Viral / analysis
  • DNA Probes
  • DNA, Viral / analysis
  • Female
  • Herpesviridae Infections / complications*
  • Herpesviridae Infections / pathology
  • Herpesvirus 6, Human* / genetics
  • Herpesvirus 6, Human* / isolation & purification
  • Humans
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / pathology
  • Lymph Nodes / microbiology
  • Lymph Nodes / pathology
  • Lymphadenitis / complications*
  • Lymphadenitis / pathology


  • Antibodies, Viral
  • DNA Probes
  • DNA, Viral