Increasing yield also increases false positives and best serves to exclude GERD

Am J Gastroenterol. 2006 Mar;101(3):460-3. doi: 10.1111/j.1572-0241.2006.00555.x.


Multiple diagnostic tests always improve diagnostic yield. However, with the addition of more true positives come more false positives. Therefore, positive predictive values likely decrease with additional testing. We show this is true even when no gold standard exists to verify the dual testing's sensitivity and specificity.

Publication types

  • Comment
  • Comparative Study
  • Editorial

MeSH terms

  • Anti-Ulcer Agents / therapeutic use
  • Gastric Acidity Determination*
  • Gastroesophageal Reflux / diagnosis*
  • Gastroesophageal Reflux / drug therapy
  • Humans
  • Monitoring, Ambulatory / statistics & numerical data*
  • Predictive Value of Tests*
  • Proton Pump Inhibitors
  • Sensitivity and Specificity
  • Statistics as Topic


  • Anti-Ulcer Agents
  • Proton Pump Inhibitors