Relationship between cyclooxygenase 8473T>C polymorphism and the risk of lung cancer: a case-control study

BMC Cancer. 2006 Mar 17;6:70. doi: 10.1186/1471-2407-6-70.

Abstract

Background: Cyclooxygenase-2 (COX-2) plays an important role in the development of lung cancer. DNA sequence variations in the COX-2 gene may lead to altered COX-2 production and/or activity, and so they cause inter-individual differences in the susceptibility to lung cancer. To test this hypothesis, we investigated the association between the 8473T>C polymorphism in the 3'-untranslated region of the COX-2 gene and the risk of lung cancer in a Korean population.

Methods: The COX-2 genotypes were determined using PCR-based primer-introduced restriction analysis in 582 lung cancer patients and in 582 healthy controls that were frequency-matched for age and gender.

Results: The distribution of the COX-2 8473T>C genotypes was not significantly different between the overall lung cancer cases and the controls. However, when the cases were categorized by the tumor histology, the combined 8473 TC + CC genotype was associated with a significantly decreased risk of adenocarcinoma as compared with the 8473 TT genotype (adjusted OR = 0.64; 95% CI = 0.46-0.90, P = 0.01). On the stratification analysis, the protective effect of the combined 8473 TC + CC genotype against adenocarcinoma was statistically significant in the males, older individuals and ever-smokers (adjusted OR = 0.59; 95% CI = 0.39-0.91, P = 0.02; adjusted OR = 0.55; 95% CI = 0.33-0.93, P = 0.03; and adjusted OR = 0.57; 95% CI = 0.37-0.87, P = 0.01, respectively).

Conclusion: These findings suggest that the COX-2 8473T>C polymorphism could be used as a marker for the genetic susceptibility to adenocarcinoma of the lung.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions
  • Adenocarcinoma / enzymology
  • Adenocarcinoma / genetics*
  • Adult
  • Aged
  • Biomarkers, Tumor*
  • Case-Control Studies
  • Cyclooxygenase 2 / genetics*
  • DNA Primers / chemistry
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Lung Neoplasms / enzymology
  • Lung Neoplasms / genetics*
  • Male
  • Middle Aged
  • Models, Statistical
  • Odds Ratio
  • Phenotype
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Risk
  • Sequence Analysis, DNA
  • Sex Factors
  • Smoking

Substances

  • 3' Untranslated Regions
  • Biomarkers, Tumor
  • DNA Primers
  • Cyclooxygenase 2