Parkinsonism and midbrain dysfunction after shunt placement for obstructive hydrocephalus

J Clin Neurosci. 2006 Apr;13(3):373-8. doi: 10.1016/j.jocn.2005.04.023. Epub 2006 Mar 20.


We report a patient in whom placement of a ventriculoperitoneal shunt for obstructive hydrocephalus secondary to non-neoplastic aqueductal stenosis was complicated by progressive parkinsonism and midbrain dysfunction. These sequelae were refractory to treatment, including shunt revision and levodopa therapy. These findings contradict the opinion from the literature that this type of parkinsonism is a reversible condition and levodopa therapy is effective for managing the symptoms. We discuss the pathophysiological mechanism of this complication.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Hydrocephalus / surgery*
  • Magnetic Resonance Imaging / methods
  • Male
  • Mesencephalon / pathology*
  • Middle Aged
  • Parkinson Disease / etiology*
  • Time Factors
  • Ventriculoperitoneal Shunt / adverse effects*