Chemical ligation--an unusual paradigm in protease inhibition

Mol Cell. 2006 Mar 17;21(6):727-8. doi: 10.1016/j.molcel.2006.03.001.


Some protease inhibitors use uncommon mechanisms to restrain the activity of their target enzymes. A recent paper in Chemistry and Biology (Lu et al., 2006) demonstrates a curious mechanism of inhibition of a caspase, relying on principles of native peptide ligation.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Caspase Inhibitors*
  • Inteins / physiology
  • Models, Biological
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology*
  • Viral Proteins / physiology


  • Caspase Inhibitors
  • Protease Inhibitors
  • Viral Proteins
  • p35 protein, Baculovirus