Silica, silicosis, and lung cancer

Isr Med Assoc J. 2006 Feb;8(2):114-8.


Evidence that crystalline silica is associated with an increased rate of lung cancer led the International Agency for Research on Cancer to conclude in 1997 that crystalline silica is a known human carcinogen. In Israel too, crystalline silica is considered as such. The decision raised a debate in the scientific arena, and a few scientists have questioned the basis upon which causality was determined. We review the literature regarding the level of evidence of crystalline silica carcinogenicity.

Publication types

  • Review

MeSH terms

  • Humans
  • Israel / epidemiology
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / etiology*
  • Occupational Exposure / adverse effects*
  • Quartz / toxicity*
  • Risk Assessment
  • Risk Factors
  • Silicosis / complications*
  • Silicosis / epidemiology


  • Quartz