Ispaghula husk may relieve gastrointestinal symptoms in ulcerative colitis in remission

Scand J Gastroenterol. 1991 Jul;26(7):747-50. doi: 10.3109/00365529108998594.


The efficiency of ispaghula husk in relieving gastrointestinal symptoms in patients with ulcerative colitis in remission was studied in a placebo-controlled trial running for 4 months. Twenty-nine patients (81%) completed the trial; four withdrew after colitis relapse (three while receiving placebo). Grading of symptoms judged ispaghula to be consistently superior to placebo (p less than 0.001) and associated with a significantly higher rate of improvement (69%) than placebo (24%) (p less than 0.001). The results show that ispaghula can be helpful in the management of gastrointestinal symptoms in quiescent ulcerative colitis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Colitis, Ulcerative / diet therapy*
  • Dietary Fiber / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psyllium / therapeutic use*
  • Surveys and Questionnaires


  • Dietary Fiber
  • Psyllium