Prefrontal hemodynamic activity predicts false memory--a near-infrared spectroscopy study

Neuroimage. 2006 Jul 15;31(4):1783-9. doi: 10.1016/j.neuroimage.2006.02.003. Epub 2006 Mar 20.


Evidence from lesion studies suggests an important role of the prefrontal cortex (PFC) in the reconstructive processes of episodic memory or memory distortion. Results from functional imaging studies imply PFC involvement during the illusionary recollection of non-experienced events. Here, we used a two-channel near-infrared spectroscopy (NIRS) system and conducted real-time monitoring of PFC hemodynamics, while subjects studied word lists and subsequently recognized unstudied items (false recognition). Bilateral increases in the oxygenated hemoglobin concentration ([oxy-Hb]) were observed during false recognition compared to true recognition, and a left PFC dominant increase of [oxy-Hb] was observed during encoding phases where subjects later claimed that they recognized unstudied words. Traces of semantic processing, reflected primarily in the left PFC activity, could eventually predict whether subjects falsely recognize non-experienced events.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cerebrovascular Circulation / physiology*
  • Data Interpretation, Statistical
  • Female
  • Hemoglobins / metabolism
  • Humans
  • Male
  • Memory / physiology*
  • Prefrontal Cortex / blood supply*
  • Prefrontal Cortex / physiology*
  • Psychomotor Performance / physiology
  • Recognition, Psychology / physiology*
  • Spectroscopy, Near-Infrared


  • Hemoglobins