Cryopyrin: In From the Cold

Immunity. 2006 Mar;24(3):241-3. doi: 10.1016/j.immuni.2006.03.004.

Abstract

Mutations in CIAS1/cryopyrin are linked to several autoinflammatory diseases. In this issue of Immunity, a critical role for cryopyrin in the caspase-1/IL-1beta axis and reveal a broader role for cryopyrin than anticipated is uncovered.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Carrier Proteins / physiology*
  • Caspase 1 / physiology*
  • Enzyme Activation
  • Immunity, Innate*
  • Interleukin-1 / physiology
  • Mice
  • NLR Family, Pyrin Domain-Containing 3 Protein

Substances

  • Carrier Proteins
  • Interleukin-1
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Nlrp3 protein, mouse
  • Caspase 1