Integrin-linked kinase and its partners: a modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization

Eur J Cell Biol. 2006 Apr;85(3-4):255-63. doi: 10.1016/j.ejcb.2005.09.002. Epub 2005 Oct 10.

Abstract

Integrin-linked kinase (ILK) represents a key component of integrin signaling complexes that functions in concert with multiple binding partners to transmit cues from the extracellular matrix environment to the actin cytoskeleton. Both gain- and loss-of-function approaches to study ILK have confirmed the essential role of this protein in regulating cell-matrix adhesion dynamics and cytoskeletal organization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / physiology*
  • Actin Cytoskeleton / ultrastructure
  • Animals
  • Cell Adhesion
  • Cell-Matrix Junctions / metabolism*
  • Extracellular Matrix / metabolism
  • Gene Expression Regulation / genetics
  • Gene Expression Regulation / physiology
  • Humans
  • Models, Biological
  • Models, Genetic
  • Protein Binding
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Serine-Threonine Kinases / physiology*
  • Signal Transduction
  • rho GTP-Binding Proteins / metabolism

Substances

  • integrin-linked kinase
  • Protein-Serine-Threonine Kinases
  • rho GTP-Binding Proteins