Integrin-linked kinase and its partners: a modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization

Etienne Boulter; Ellen Van Obberghen-Schilling

doi:10.1016/j.ejcb.2005.09.002

Integrin-linked kinase and its partners: a modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization

Eur J Cell Biol. 2006 Apr;85(3-4):255-63. doi: 10.1016/j.ejcb.2005.09.002. Epub 2005 Oct 10.

Authors

Etienne Boulter¹, Ellen Van Obberghen-Schilling

Affiliation

¹ Institute of Signaling, Developmental Biology and Cancer Research, CNRS-UMR6543, Centre Antoine Lacassagne, 33 Avenue de Valombrose, F-06189 Nice, France.

PMID: 16546570
DOI: 10.1016/j.ejcb.2005.09.002

Abstract

Integrin-linked kinase (ILK) represents a key component of integrin signaling complexes that functions in concert with multiple binding partners to transmit cues from the extracellular matrix environment to the actin cytoskeleton. Both gain- and loss-of-function approaches to study ILK have confirmed the essential role of this protein in regulating cell-matrix adhesion dynamics and cytoskeletal organization.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Actin Cytoskeleton / physiology*
Actin Cytoskeleton / ultrastructure
Animals
Cell Adhesion
Cell-Matrix Junctions / metabolism*
Extracellular Matrix / metabolism
Gene Expression Regulation / genetics
Gene Expression Regulation / physiology
Humans
Models, Biological
Models, Genetic
Protein Binding
Protein-Serine-Threonine Kinases / genetics
Protein-Serine-Threonine Kinases / metabolism
Protein-Serine-Threonine Kinases / physiology*
Signal Transduction
rho GTP-Binding Proteins / metabolism

Substances

integrin-linked kinase
Protein-Serine-Threonine Kinases
rho GTP-Binding Proteins