Induction of withdrawal-like symptoms in a small randomized, controlled trial of opioid blockade in frequent tanners

J Am Acad Dermatol. 2006 Apr;54(4):709-11. doi: 10.1016/j.jaad.2005.11.1059.


Frequent tanning has reinforcing properties. We tested whether opioid antagonism blocks potential reinforcing effect of indoor tanning in 8 frequent tanners and 8 infrequent tanner control subjects. Opioid blockade reduced ultraviolet preference in frequent tanners. Four of 8 frequent tanners, but no infrequent tanners, exhibited withdrawal-like symptoms with naltrexone administration. A limitation of this study is its small size.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Beauty Culture*
  • Behavior, Addictive / drug therapy*
  • Double-Blind Method
  • Humans
  • Naltrexone / adverse effects
  • Naltrexone / therapeutic use*
  • Narcotic Antagonists / adverse effects
  • Narcotic Antagonists / therapeutic use*
  • Skin / radiation effects*
  • Substance Withdrawal Syndrome / etiology
  • Ultraviolet Rays*


  • Narcotic Antagonists
  • Naltrexone