Polymer chain models of DNA and chromatin

Eur Phys J E Soft Matter. 2006 Mar;19(3):241-9. doi: 10.1140/epje/i2005-10067-9. Epub 2006 Mar 20.


Many properties of the genome in the cell nucleus can be understood by modeling DNA and chromatin as a flexible polymer chain. This article introduces into current models for such a coarse-grained description and reviews some recent results from our own group. Examples given are the unrolling of DNA from the histone core and the response of the 30 nm chromatin fiber to mechanical stretching.

MeSH terms

  • Cell Nucleus / ultrastructure
  • Chromatin / chemistry*
  • Computer Simulation
  • DNA / chemistry*
  • DNA / genetics
  • Genome
  • Models, Molecular
  • Monte Carlo Method
  • Nanostructures
  • Nucleosomes / ultrastructure


  • Chromatin
  • Nucleosomes
  • DNA