Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension

Respirology. 2006 Mar;11(2):158-63. doi: 10.1111/j.1440-1843.2006.00821.x.


Objective: Monocyte chemoattractant protein-1 (MCP-1), a pro-inflammatory chemokine, has potent chemoattractant activity for monocytes/macrophages. We sought to investigate the clinical significance of MCP-1 in idiopathic pulmonary arterial hypertension (IPAH).

Methods: This study included 28 patients with IPAH, seven patients with pulmonary arterial hypertension (PAH) related to collagen vascular disease, and 13 healthy subjects. Plasma MCP-1 levels were measured together with serum IL-6 and tumour necrosis factor-alpha (TNF-alpha) levels.

Results: Circulating levels of MCP-1, IL-6 and TNF-alpha were significantly higher in patients with IPAH than in healthy controls, although they were lower than in patients with PAH related to collagen vascular disease. Plasma MCP-1 did not significantly correlate with any haemodynamic variables. However, plasma MCP-1 levels correlated negatively with the disease duration (time from symptom onset).

Conclusions: Plasma MCP-1 levels were elevated in patients with IPAH, and this elevation was particularly marked in the early stage of disease. Taking into account the chemoattractant activity of MCP-1, these results imply a contribution of MCP-1 to the development of pulmonary hypertension.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Biomarkers / blood
  • Chemokine CCL2 / blood*
  • Disease Progression
  • Female
  • Humans
  • Hypertension, Pulmonary / blood*
  • Hypertension, Pulmonary / physiopathology
  • Immunoenzyme Techniques
  • Interleukin-6 / blood
  • Male
  • Middle Aged
  • Pulmonary Wedge Pressure / physiology
  • Severity of Illness Index
  • Tumor Necrosis Factor-alpha / metabolism


  • Biomarkers
  • CCL2 protein, human
  • Chemokine CCL2
  • Interleukin-6
  • Tumor Necrosis Factor-alpha