A smoking cessation intervention for the methadone-maintained

Addiction. 2006 Apr;101(4):599-607. doi: 10.1111/j.1360-0443.2006.01406.x.

Abstract

Aim: To test, in combination with the nicotine patch, the incremental efficacy of a maximal, tailored behavioral treatment over a minimal treatment for smoking cessation.

Design: Randomized clinical trial with 6-month follow-up.

Setting: Five methadone maintenance treatment centers in Rhode Island.

Participants: Three hundred and eighty-three methadone-maintained smokers.

Intervention: Participants were assigned randomly to nicotine patch (8-12 weeks) plus either (1) a baseline tailored brief motivational intervention, a quit date behavioral skills counseling session and a relapse prevention follow-up session (Max) or (2) brief advice using the National Cancer Institute's 4 As model (Min). An intent-to-treat analysis with those lost to follow-up assumed to smoke was used.

Measurements: Carbon monoxide (CO)-confirmed 7-day point smoking cessation prevalence at 3 and 6 months, and self-reported numbers of cigarettes smoked per day.

Findings: Participants had a mean age of 40 years, were 53% male, 78% Caucasian, smoked 26.7 (+/- 12.2) cigarettes/day and had a mean methadone dose of 95.5 mg. At 3 months, 317 (83%) were re-interviewed; at 6 months, 312 (82%) were re-interviewed. The intent-to-treat, 7-day point prevalence estimate of cessation was 5.2% in the Max group and 4.7% in the Min group (P=0.81) at 6 months. In logistic models with treatment condition, age, gender, race, Fagerström Test for Nicotine Dependence and cigarettes per day as covariates, males were more likely to be abstinent at 3 months (OR 4.67; P=0.003) and 6 months (OR 4.01; P=0.015).

Conclusion: A tailored behavioral intervention did not increase quit rates over patch and minimal treatment. Smoking cessation rates in methadone-maintained smokers are low, with men having greater success.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Combined Modality Therapy
  • Female
  • Humans
  • Male
  • Methadone / therapeutic use*
  • Middle Aged
  • Nicotine / therapeutic use
  • Opioid-Related Disorders / complications*
  • Opioid-Related Disorders / rehabilitation
  • Psychotherapy, Brief / methods
  • Smoking Cessation / methods*
  • Tobacco Use Disorder / complications*
  • Tobacco Use Disorder / rehabilitation
  • Treatment Outcome

Substances

  • Nicotine
  • Methadone