Recurrent glomerular diseases after renal transplantation

Transplant Proc. 2006 Mar;38(2):470-2. doi: 10.1016/j.transproceed.2006.01.028.

Abstract

Introduction: Recurrent glomerular diseases are important causes of graft dysfunction after renal transplantation. As the outcomes of transplantation continue to improve, the problem of recurrent diseases in the transplanted kidney have become evident. The purpose of our study was to determine the risk factors for and the incidence of recurrence in the posttransplant period as well as their impact on graft survival rates.

Method: We retrospectively analyzed 49 patients with glomerular diseases due to membranoproliferative glomerulonephritis (n = 26); focal segmental glomerulosclerosis (FSGS, n = 18); and systemic lupus erythematosus (n = 5). The mean follow-up was 9.5 years.

Results: Recurrent disease was detected in 30 of 49 patients after a mean posttransplant follow-up of 28.1 months (range = 1 to 157) and their average graft survival was 41.3 months. Nineteen patients were recurrence-free with a mean graft survival of 79.4 (range = 15 to 158) months (P < .05). One patient with FSGS, showed disease-recurrence in her third transplant after having experienced recurrences in the former grafts. In all six patients with HLA haplotype B8, recurrence was observed at a mean of 19.5 +/- 9.8 months. The only risk factor that was identified was this HLA haplotype.

Conclusion: Recurrent disease a significant problem after renal transplantation is associated with decreased graft survival. The donor HLA type may be associated with risk, which should be clearly discussed with both the living donor and the recipient candidate.

MeSH terms

  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Glomerulonephritis / epidemiology*
  • Glomerulonephritis, Membranoproliferative / epidemiology
  • Glomerulosclerosis, Focal Segmental
  • Graft Rejection / epidemiology
  • Histocompatibility Testing
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney Transplantation / adverse effects*
  • Kidney Transplantation / immunology
  • Lupus Erythematosus, Systemic / surgery
  • Male
  • Postoperative Complications / classification
  • Postoperative Complications / epidemiology
  • Recurrence
  • Retrospective Studies
  • Time Factors

Substances

  • Immunosuppressive Agents