Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 20 (2), 253-83

The Inherited Genetics of Pancreatic Cancer and Prospects for Secondary Screening

Affiliations
Review

The Inherited Genetics of Pancreatic Cancer and Prospects for Secondary Screening

Louis J Vitone et al. Best Pract Res Clin Gastroenterol.

Abstract

It is estimated that pancreatic cancer has a familial component in approximately 5-10% of cases. Some of these cases are part of a defined cancer syndrome with a known gene mutation but in the remaining the causative gene remains unknown. In recent years, a better understanding of the molecular events that occur in the progression model of pancreatic cancer has lead to the development of secondary screening programmes with the aim of identifying early precursor lesions or pre-invasive cancer at a stage amenable to curative resection. High-risk groups who have an inherited predisposition for pancreatic cancer form the ideal group to study in developing a robust screening programme. Multimodality screening using computed tomography and endoluminal ultrasound in combination with molecular analysis of pancreatic juice are proving promising as diagnostics tools or at least serving as predictors of risk over a defined period.

Similar articles

See all similar articles

Cited by 15 PubMed Central articles

See all "Cited by" articles

Substances

LinkOut - more resources

Feedback