In vivo administration of TNF-alpha prevents EMC-M virus induced viral encephalitis

Int Immunol. 1991 Jul;3(7):641-5. doi: 10.1093/intimm/3.7.641.


EMC-M virus causes a monophasic paralytic syndrome characterized by encephalitic lesions in the brain and patchy demyelinating lesions in the spinal cord and nerve roots of BALB/c mice. Since the replication of EMC virus in vitro is inhibited by tumor necrosis factor (TNF)-alpha we have studied the effect of in vivo administration of this cytokine on the acute disease. Our studies show that periodic administration of TNF-alpha to animals infected with EMC-M reduces viral titers in the brain, and decreases the degree of clinical paralysis and the severity of the inflammatory lesions in the brain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Astrocytes / microbiology
  • Brain / microbiology
  • Encephalitis / prevention & control*
  • Female
  • Mice
  • Mice, Inbred BALB C
  • Picornaviridae / drug effects
  • Picornaviridae Infections / microbiology
  • Picornaviridae Infections / prevention & control*
  • Tumor Necrosis Factor-alpha / administration & dosage
  • Tumor Necrosis Factor-alpha / pharmacology*
  • Virus Replication / drug effects


  • Tumor Necrosis Factor-alpha