One-year outcomes of a randomized clinical trial treating depression in low-income minority women

J Consult Clin Psychol. 2006 Feb;74(1):99-111. doi: 10.1037/0022-006X.74.1.99.


This study examines 1-year depressive symptom and functional outcomes of 267 predominantly lowincome, young minority women randomly assigned to antidepressant medication, group or individual cognitive- behavioral therapy (CBT), or community referral. Seventy-six percent assigned to medications received 9 or more weeks of guideline-concordant doses of medications; 36% assigned to psychotherapy received 6 or more CBT sessions. Intent-to-treat, repeated measures analyses revealed that medication (p=.001) and CBT (p=.02) were superior to community referral in lowering depressive symptoms across 1-year follow-up. At Month 12, 50.9% assigned to antidepressants, 56.9% assigned to CBT, and 37.1% assigned to community referral were no longer clinically depressed. These findings suggest that both antidepressant medications and CBT result in clinically significant decreases in depression for low-income minority women.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antidepressive Agents, Second-Generation / administration & dosage*
  • Bupropion / administration & dosage*
  • Cognitive Behavioral Therapy*
  • Combined Modality Therapy
  • Depressive Disorder / therapy*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Humans
  • Minority Groups / psychology*
  • Paroxetine / administration & dosage*
  • Patient Education as Topic
  • Poverty / psychology*
  • Psychotherapy, Group*


  • Antidepressive Agents, Second-Generation
  • Bupropion
  • Paroxetine