B cell immunobiology in disease: evolving concepts from the clinic

Annu Rev Immunol. 2006;24:467-96. doi: 10.1146/annurev.immunol.24.021605.090517.

Abstract

The pathogenic roles of B cells in autoimmune diseases occur through several mechanistic pathways that include autoantibodies, immune complexes, dendritic and T cell activation, cytokine synthesis, chemokine-mediated functions, and ectopic neolymphogenesis. Each of these pathways participate to different degrees in autoimmune diseases. The use of B cell-targeted and B cell subset-targeted therapies in humans is illuminating the mechanisms at work in a variety of human autoimmune diseases. In this review, we highlight some of these recent findings that provide insights into both murine models of autoimmunity and human autoimmune diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use
  • Antigen-Antibody Complex
  • Antigens, CD
  • Autoantibodies
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / pathology
  • Autoimmune Diseases / therapy*
  • Autoimmunity
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / pathology
  • Cell Survival
  • Humans
  • Lymphocyte Activation
  • Lymphocyte Depletion
  • Lymphoid Tissue / immunology
  • Lymphoid Tissue / pathology
  • Mice
  • Models, Immunological
  • Primates
  • Receptors, Antigen, B-Cell
  • T-Lymphocytes / immunology

Substances

  • Antibodies, Monoclonal
  • Antigen-Antibody Complex
  • Antigens, CD
  • Autoantibodies
  • Receptors, Antigen, B-Cell