Correspondence re: Cecchin et al., Carboxylesterase isoform 2 mRNA expression in peripheral blood mononuclear cells is a predictive marker of the irinotecan to SN38 activation step in colorectal cancer patients. Clin Cancer Res 2005;11:6901-7

Clin Cancer Res. 2006 Mar 15;12(6):1942; author reply 1942-3. doi: 10.1158/1078-0432.CCR-05-2321.
No abstract available

Publication types

  • Letter
  • Comment

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biomarkers, Tumor / genetics
  • Camptothecin / administration & dosage
  • Camptothecin / analogs & derivatives
  • Carboxylesterase / genetics*
  • Colorectal Neoplasms / blood
  • Colorectal Neoplasms / drug therapy*
  • Colorectal Neoplasms / genetics
  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Irinotecan
  • Isoenzymes / genetics
  • Leukocytes, Mononuclear / cytology
  • Leukocytes, Mononuclear / enzymology
  • Leukocytes, Mononuclear / metabolism*
  • Predictive Value of Tests
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism

Substances

  • Biomarkers, Tumor
  • Isoenzymes
  • RNA, Messenger
  • Irinotecan
  • Carboxylesterase
  • Camptothecin