RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet

Infect Immun. 2006 Apr;74(4):2453-6. doi: 10.1128/IAI.74.4.2453-2456.2006.

Abstract

The rlrA pathogenicity islet in Streptococcus pneumoniae TIGR4 encodes three surface proteins, RrgA, RrgB, and RrgC, and three sortase enzymes. Using transmission electron microscopy, cell fractionation, cell wall sorting signal domain swapping, and Western blotting, we show that RrgA and RrgB are incorporated into a multisubunit pilus in S. pneumoniae.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoacyltransferases / genetics
  • Aminoacyltransferases / physiology
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology
  • Cysteine Endopeptidases / genetics
  • Cysteine Endopeptidases / physiology
  • Fimbriae Proteins / chemistry
  • Fimbriae Proteins / genetics*
  • Fimbriae Proteins / immunology
  • Fimbriae, Bacterial / enzymology
  • Fimbriae, Bacterial / genetics*
  • Fimbriae, Bacterial / ultrastructure
  • Genomic Islands / genetics*
  • Genomic Islands / immunology
  • Microscopy, Electron, Transmission
  • Protein Structure, Tertiary / genetics
  • Streptococcus pneumoniae / enzymology
  • Streptococcus pneumoniae / genetics*
  • Streptococcus pneumoniae / immunology
  • Streptococcus pneumoniae / pathogenicity*
  • Virulence Factors / chemistry
  • Virulence Factors / genetics*
  • Virulence Factors / immunology

Substances

  • Bacterial Proteins
  • RrgA protein, Streptococcus pneumoniae
  • Virulence Factors
  • Fimbriae Proteins
  • Aminoacyltransferases
  • sortase A
  • Cysteine Endopeptidases