Abstract
Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antidiarrheals / pharmacology
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Disease Models, Animal
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Gastrointestinal Motility / drug effects
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Gastrointestinal Motility / immunology*
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Giardiasis / drug therapy
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Giardiasis / immunology*
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Giardiasis / parasitology
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Immunity, Active
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Loperamide / pharmacology
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, SCID
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Nitric Oxide Synthase Type I / deficiency
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Nitric Oxide Synthase Type I / genetics
Substances
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Antidiarrheals
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Loperamide
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Nitric Oxide Synthase Type I