Akt1 in endothelial cell and angiogenesis

Cell Cycle. 2006 Mar;5(5):512-8. doi: 10.4161/cc.5.5.2538. Epub 2006 Mar 1.


Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as cancer and ischemic injury.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Endothelial Cells / metabolism*
  • Neovascularization, Physiologic*
  • Phosphorylation
  • Protein Isoforms
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction


  • Protein Isoforms
  • Proto-Oncogene Proteins c-akt