Evaluation of p53 codon 72 polymorphism in adenocarcinomas of the colon and rectum in La Plata, Argentina

World J Gastroenterol. 2006 Mar 7;12(9):1426-9. doi: 10.3748/wjg.v12.i9.1426.


Aim: To evaluate the potential association between p53 codon 72 polymorphism and sporadic colorectal adenocarcinoma development,and human papillomavirus (HPV) infection.

Methods: One-hundred and nine controls and 53 patients with colon cancer from the city of La Plata, Argentina were analyzed. p53 codon 72 genotypes and HPV infection were identified using allele-specific polymerase chain reaction and nested polymerase chain reaction, respectively.

Results: The differences in the distribution of p53 codon 72 polymorphism between the cases and controls were statistically significant. The arginine allele had a prevalence of 0.65 in controls and 0.77 in cases. The corresponding odds ratio for the homozygous arginine genotype was 2.08 (95% CI, 1.06-4.05; P<0.05). Lack of association was found between p53 polymorphism and HPV infection in the set of adenocarcinomas.

Conclusion: The findings of the present study indicate that p53 codon 72 arginine homozygous genotype may represent a genetic predisposing factor for colon cancer development. However,further studies are needed in order to elucidate the role of p53 codon 72 polymorphism in colorectal cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Argentina
  • Case-Control Studies
  • Causality
  • Codon / genetics*
  • Colorectal Neoplasms / genetics*
  • Genes, p53*
  • Genetic Predisposition to Disease
  • Humans
  • Middle Aged
  • Papillomaviridae
  • Papillomavirus Infections / genetics
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*


  • Codon