[Severe vitamin-D deficiency in more than half of the immigrant pregnant women of non-western origin and their newborns]

Ned Tijdschr Geneeskd. 2006 Mar 4;150(9):495-9.
[Article in Dutch]


Objective: To determine the prevalence of vitamin-D deficiency in pregnant women and their newborns.

Design: Descriptive.

Method: During the period of one year (April 2004-April 2005) 545 pregnant women of Dutch/European origin and 131 pregnant women of non-Western origin (mainly Turkish and Moroccan) were studied during their 10th and/or 30th week of pregnancy for calcidiol (vitamin-D) and calcium levels. The study took place in the Amersfoort region in the center of the Netherlands. In addition, cord blood samples were taken for vitamin-D and calcium levels from the 442 and 81 Dutch/European and non-Western newborns respectively.

Results: A severe deficiency was found (calcidiol < 20 nmol/l) in 55% of non-European women compared to 5% of Dutch/West-European women. From the cord blood samples, a severe vitamin-D deficiency (calcidiol < 13 nmol/l) was found in 54% of the newborns of non-European origin compared to 6% of the Dutch/West-European newborns. Vitamin-D concentrations in pregnant women at term were strongly correlated to the concentrations in the newborns' cord blood (R = 0.84). The calcium levels of pregnant women and newborns did not differ significantly between both population groups.

Conclusion: More than half of the non-European pregnant women and their newborns had a severe vitamin-D deficiency. Screening for vitamin D deficiency and adequate suppletion for this risk group appears to be necessary. The causes and consequences of vitamin-D deficiency in pregnancy are discussed.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Emigration and Immigration*
  • Female
  • Fetal Blood / chemistry*
  • Humans
  • Infant, Newborn / blood*
  • Morocco / ethnology
  • Netherlands / epidemiology
  • Nutritional Status
  • Pregnancy
  • Pregnancy Complications / blood
  • Pregnancy Complications / ethnology*
  • Prevalence
  • Turkey / ethnology
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / ethnology*


  • Vitamin D