Abstract
The influence of anaprilin, oxprenolol, nonachlazine, prazosin and levodopa on the clinical course and haemodynamics was investigated in 138 patients with ischaemic heart disease in whom selective coronary angiography had revealed an up to 50 percent stenosis of one of coronary arteries. The clinical picture of IHD patients with a high tolerance of physical exercise was characterized by a preponderance of spontaneous angina pectoris accompanied by painless myocardial ischaemia. A certain role in the genesis of these disturbances is played by the relative increase in the activity of alpha 1-adrenoreceptors and decrease in beta-adrenoreceptor activity. Prazosin and nonachlazine in monotherapy reduced the number of anginal attacks and episodes of painless myocardial ischaemia.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Adult
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Angina Pectoris / drug therapy*
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Angina Pectoris / etiology
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Coronary Artery Disease / complications
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Coronary Artery Disease / drug therapy
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Coronary Artery Disease / physiopathology*
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Coronary Disease / drug therapy
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Coronary Disease / etiology
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Coronary Disease / physiopathology
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Double-Blind Method
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Exercise Test
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Hemodynamics / drug effects*
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Humans
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Levodopa / pharmacology
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Levodopa / therapeutic use
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Middle Aged
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Nonachlazine / pharmacology
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Nonachlazine / therapeutic use*
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Oxprenolol / pharmacology
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Oxprenolol / therapeutic use*
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Prazosin / pharmacology
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Prazosin / therapeutic use*
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Propranolol / pharmacology
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Propranolol / therapeutic use*
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Receptors, Adrenergic, alpha / drug effects
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Receptors, Adrenergic, beta / drug effects
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Receptors, Adrenergic, beta / physiology
Substances
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Receptors, Adrenergic, alpha
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Receptors, Adrenergic, beta
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Levodopa
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Oxprenolol
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Nonachlazine
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Propranolol
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Prazosin