Plasma fibrinogen and lung function: the CARDIA Study

Int J Epidemiol. 2006 Aug;35(4):1001-8. doi: 10.1093/ije/dyl049. Epub 2006 Mar 22.


Background: We hypothesized that fibrinogen, as a marker of chronic inflammation, is inversely associated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) in healthy persons.

Methods: The CARDIA cohort started in 1985 and included black and white men and women, aged 18-30, from the general population. Spirometry testing conducted at years 5 and 10 [FVC, FEV(1), and their ratio (FEV(1)/FVC)] was studied relative to plasma fibrinogen levels measured at year 5 (cross-sectional n = 4,040) and at year 7 (longitudinal n = 3,001), controlling for race, sex, age, height, smoking, asthma, body mass index, physical activity, birth control pill use, and alcohol intake.

Results: In cross-sectional analyses, FVC at year 5 was lower by 166 ml (95% confidence interval 116-216 ml) in the highest vs lowest year 5 fibrinogen quartile. At year 10, holding year 5 FVC and change in fibrinogen (year 7-year 5) constant, the difference in FVC between the highest and the lowest year 5 fibrinogen quartiles widened by 67 ml (95% CI 31-103 ml). The corresponding differences for FEV(1) were 166 ml (95% CI 146-253 ml) at year 5 and 45 ml (95% CI 11-80 ml) widening by year 10. The FEV(1)/FVC ratio was unrelated to plasma fibrinogen.

Conclusion: These findings are consistent with the hypothesis that fibrinogen, possibly as a marker for chronic low-grade inflammation, is associated with modest deterioration of lung function in healthy young adults.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Alcohol Drinking
  • Biomarkers / blood
  • Body Mass Index
  • Contraceptives, Oral
  • Cross-Sectional Studies
  • Ethnicity
  • Exercise
  • Female
  • Fibrinogen / analysis*
  • Forced Expiratory Volume
  • Humans
  • Linear Models
  • Longitudinal Studies
  • Lung / physiopathology
  • Lung Diseases / blood*
  • Lung Diseases / physiopathology
  • Male
  • Sex Factors
  • Smoking
  • Vital Capacity


  • Biomarkers
  • Contraceptives, Oral
  • Fibrinogen