Recent advances in Cys-loop receptor structure and function

Nature. 2006 Mar 23;440(7083):448-55. doi: 10.1038/nature04708.


Throughout the nervous system, moment-to-moment communication relies on postsynaptic receptors to detect neurotransmitters and change the membrane potential. For the Cys-loop superfamily of receptors, recent structural data have catalysed a leap in our understanding of the three steps of chemical-to-electrical transduction: neurotransmitter binding, communication between the binding site and the barrier to ions, and opening and closing of the barrier. The emerging insights might be expected to explain how mutations of receptors cause neurological disease, but the opposite is generally true. Namely, analyses of disease-causing mutations have clarified receptor structure-function relationships as well as mechanisms governing the postsynaptic response.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylcholine / metabolism
  • Animals
  • Cysteine
  • Humans
  • Ion Channel Gating
  • Myasthenic Syndromes, Congenital / genetics
  • Myasthenic Syndromes, Congenital / metabolism
  • Neurotransmitter Agents / metabolism
  • Nicotinic Agonists / metabolism
  • Protein Conformation
  • Receptors, Nicotinic / chemistry*
  • Receptors, Nicotinic / metabolism
  • Structure-Activity Relationship
  • Synapses / physiology
  • Synaptic Transmission / physiology


  • Neurotransmitter Agents
  • Nicotinic Agonists
  • Receptors, Nicotinic
  • Cysteine
  • Acetylcholine