Effect of white wine consumption on oxidative stress markers and homocysteine levels

Physiol Res. 2007;56(2):203-212. doi: 10.33549/physiolres.930936. Epub 2006 Mar 23.


The aim of this study was to assess the influence of regular daily consumption of white wine on oxidative stress and cardiovascular risk markers. Forty-two healthy male volunteers consumed 375 ml of white wine daily. Each participant provided three venous blood samples (before wine consumption, following the wine consumption period and again a month later). Levels of superoxide dismutase, glutathione peroxidase, reduced glutathione, total antioxidant capacity, total cholesterol, HDL-cholesterol, apolipoprotein A I, apolipoprotein B, triglycerides, paraoxonase 1, C-reactive protein, homocysteine, thiobarbituric acid reactive substances (TBARS) and advanced oxidation protein products (AOPP) were measured. Immediately following the month of white wine consumption there was a significant increase in HDL-cholesterol (p<0.0001), paraoxonase 1 (p<0.001), glutathione peroxidase (p<0.001) and reduced glutathione (p<0.01) levels, a decrease in superoxide dismutase activities (p<0.0001), and a decrease in oxidation protein products (p<0.001) and TBARS (p<0.05) concentrations. However, there was also a clear increase in homocysteine (p<0.0001) after a month of white wine consumption. The results of our non-placebo controlled trial suggest that regular daily white wine consumption is associated not only with both antioxidative and antiatherogenic effects but also with a potentially proatherogenic increase of homocysteine concentrations.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alcohol Drinking / blood
  • Alcohol Drinking / metabolism*
  • Apolipoproteins / blood
  • Aryldialkylphosphatase / blood
  • Biomarkers / blood*
  • C-Reactive Protein / metabolism
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / etiology*
  • Cardiovascular Diseases / metabolism
  • Cholesterol / blood
  • Cohort Studies
  • Czech Republic
  • Glutathione / blood
  • Glutathione Peroxidase / blood
  • Homocysteine / blood*
  • Humans
  • Liver / enzymology
  • Male
  • Oxidative Stress*
  • Risk Factors
  • Superoxide Dismutase / blood
  • Thiobarbituric Acid Reactive Substances / metabolism
  • Triglycerides / blood
  • Wine*


  • Apolipoproteins
  • Biomarkers
  • Thiobarbituric Acid Reactive Substances
  • Triglycerides
  • Homocysteine
  • C-Reactive Protein
  • Cholesterol
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Aryldialkylphosphatase
  • PON1 protein, human
  • Glutathione