Antihypertensive effect of an extract of Passiflora edulis rind in spontaneously hypertensive rats

Biosci Biotechnol Biochem. 2006 Mar;70(3):718-21. doi: 10.1271/bbb.70.718.


Orally administered methanol extract of Passiflora edulis rind (10 mg/kg or 50 mg/kg) or luteolin (50 mg/kg), which is one of consistent polyphenols of the extract, significantly lowered systolic blood pressure in spontaneously hypertensive rats (SHRs). Quantitative analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) showed that the extract contained 20 microg/g dry weight of luteolin and 41 microg/g dry weight of luteolin-6-C-glucoside. It also contained gamma-aminobutyric acid (GABA, 2.4 mg/g dry weight by LC-MS/MS or 4.4 mg/g dry weight by amino acid analysis) which has been reported to be an antihypertensive material. Since the extract contained a relatively high concentration of GABA, the antihypertensive effect of the extract in SHRs might be due mostly to the GABA-induced antihypertensive effect and partially to the vasodilatory effect of polyphenols including luteolin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antihypertensive Agents / administration & dosage
  • Antihypertensive Agents / pharmacology*
  • Blood Pressure / drug effects
  • Chromatography, Liquid
  • Hypertension / drug therapy
  • Passiflora / chemistry*
  • Phytotherapy
  • Plant Bark / chemistry
  • Plant Extracts / pharmacology
  • Rats
  • Rats, Inbred SHR


  • Antihypertensive Agents
  • Plant Extracts