CO2 Supply Induces the Growth of Symbiobacterium Thermophilum, a Syntrophic Bacterium

Biosci Biotechnol Biochem. 2006 Mar;70(3):753-6. doi: 10.1271/bbb.70.753.


Symbiobacterium thermophilum is a unique syntrophic bacterium that exhibits marked growth only in coculture with a cognate Bacillus sp. In this study, we found that the bacterium is capable of marked mono-growth when supplied with CO2 or bicarbonate. The evidence suggests that the genetic defect for carbonic anhydrase in this bacterium is a reason for the syntrophic property based on CO2 requirement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinobacteria / cytology*
  • Actinobacteria / drug effects*
  • Actinobacteria / metabolism
  • Carbon Dioxide / pharmacology*
  • Carbonic Anhydrases / genetics
  • Carbonic Anhydrases / metabolism
  • Cell Proliferation / drug effects
  • Escherichia coli / cytology
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Escherichia coli / metabolism
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism
  • Mutation / genetics


  • Escherichia coli Proteins
  • Carbon Dioxide
  • Carbonic Anhydrases
  • YadF protein, E coli