Pathogenetic mechanisms in thyroid follicular-cell neoplasia

Nat Rev Cancer. 2006 Apr;6(4):292-306. doi: 10.1038/nrc1836.


Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent advances have improved our understanding of its pathogenesis; these include the identification of genetic alterations that activate a common effector pathway involving the RET-Ras-BRAF signalling cascade, and other unique chromosomal rearrangements. Some of these have been associated with radiation exposure as a pathogenetic mechanism. Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell-cycle control elements seem to affect tumour progression. This information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenocarcinoma, Follicular / genetics*
  • Adenocarcinoma, Follicular / pathology
  • Animals
  • Chromosome Aberrations
  • Humans
  • Proto-Oncogene Proteins / genetics
  • Thyroid Neoplasms / genetics*
  • Thyroid Neoplasms / pathology


  • Proto-Oncogene Proteins