Protein-tyrosine phosphatases and cancer

Nat Rev Cancer. 2006 Apr;6(4):307-20. doi: 10.1038/nrc1837.


Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer drugs have been introduced that target these enzymes. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs). Recent evidence has shown that PTPs can function as tumour suppressors. In addition, some PTPs, including SHP2, positively regulate the signalling of growth-factor receptors, and can be oncogenic. An improved understanding of how these enzymes function and how they are regulated might aid the development of new anticancer agents.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • ErbB Receptors / metabolism
  • Humans
  • Neoplasms / enzymology*
  • Neoplasms / therapy
  • Phosphorylation
  • Protein Tyrosine Phosphatases / genetics
  • Protein Tyrosine Phosphatases / metabolism*
  • Tyrosine


  • Tyrosine
  • ErbB Receptors
  • Protein Tyrosine Phosphatases