Sequence analysis of peptides bound to MHC class II molecules

Nature. 1991 Oct 17;353(6345):622-7. doi: 10.1038/353622a0.


CD4 T cells recognize peptide fragments of foreign proteins bound to self class II molecules of the major histocompatibility complex (MHC). Naturally processed peptide fragments bound to MHC class II molecules are peptides of 13-17 amino acids which appear to be precessively truncated from the carboxy terminus, perhaps after binding to the MHC class II molecule. The finding of predominant self peptides has interesting implications for antigen processing and self-non-self discrimination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Histocompatibility Antigens Class II / metabolism*
  • Leukemia Virus, Murine / chemistry
  • Lymphoma, B-Cell
  • Membrane Glycoproteins / analysis
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / immunology
  • Mice
  • Molecular Sequence Data
  • Peptide Fragments / chemistry*
  • Peptide Fragments / immunology
  • Peptide Fragments / metabolism
  • Retroviridae Proteins, Oncogenic / chemistry
  • Retroviridae Proteins, Oncogenic / immunology
  • Tumor Cells, Cultured
  • Viral Envelope Proteins / chemistry
  • Viral Envelope Proteins / immunology


  • Histocompatibility Antigens Class II
  • I-E-antigen
  • Membrane Glycoproteins
  • Peptide Fragments
  • Retroviridae Proteins, Oncogenic
  • Viral Envelope Proteins