Alkaloids from the roots of Aconitum pseudo-laeve var. erectum

J Nat Prod. 2006 Mar;69(3):400-2. doi: 10.1021/np058073p.

Abstract

One new quinazoline (1) and two new norditerpenoid (2 and 3) alkaloids along with 10 known compounds were isolated from the roots of Aconitum pseudo-laeve var. erectum. The new alkaloids were assigned as 2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoic acid methyl ester (1), 18-O-2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoyllycoctonine (2), and 14-O-acetyl-8-O-methyl-18-O-2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoylcammaconine (3). The structures of the new alkaloids were established by spectroscopic methods. This is the first report of the 2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoyl ester group being found as an acyl substituent in norditerpenoid alkaloids (compounds 2 and 3).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aconitine* / analogs & derivatives
  • Aconitine* / chemistry
  • Aconitine* / isolation & purification
  • Aconitum / chemistry*
  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification*
  • Korea
  • Molecular Structure
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Quinazolines / chemistry*
  • Quinazolines / isolation & purification*
  • Structure-Activity Relationship

Substances

  • Alkaloids
  • Quinazolines
  • Aconitine