(+)-N-Deoxymilitarinone A, a neuritogenic pyridone alkaloid from the insect pathogenic fungus Paecilomyces farinosus

J Nat Prod. 2006 Mar;69(3):436-8. doi: 10.1021/np050418g.

Abstract

A new pyridone alkaloid, (+)-N-deoxymilitarinone A (1), was isolated from Paecilomyces farinosus RCEF 0097 along with the related metabolites, militarinone D and militarinone B. The sterol 22E,4R-ergosta-7,22-diene-3beta,5alpha,6beta,9alpha-tetraol was also identified. The structures were established by spectroscopic methods, in particular with the aid of extensive NMR experiments. Compound 1 induced neurite sprouting in PC 12 cells when tested at 33 and 100 microM concentrations. A cytotoxic effect was observed in human neurons (IMR-32) at a concentration of 100 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • China
  • Humans
  • Lepidoptera
  • Molecular Structure
  • Nerve Growth Factors / chemistry
  • Nerve Growth Factors / isolation & purification*
  • Nerve Growth Factors / pharmacology
  • Neurons / drug effects
  • PC12 Cells
  • Paecilomyces / chemistry*
  • Pyridones / chemistry
  • Pyridones / isolation & purification*
  • Pyridones / pharmacology
  • Rats

Substances

  • (+)-N-deoxymilitarinone A
  • Alkaloids
  • Nerve Growth Factors
  • Pyridones
  • militarinone B
  • militarinone D