Abstract
The cytotoxic effects of seven constituents isolated from Duguetia glabriuscula were evaluated against Hep2 human larynx carcinoma cells. The cytotoxicity exhibited by beta-sitosterol was as strong as that of cis-platin. (+)-Alloaromadendran-10,14beta-diol caused inhibition of cellular growth with IC50 values lower than 25 microg/ml, a feature that was considered as revealing significant activity. Polycarpol showed borderline cytotoxicity, whereas the other compounds were inactive.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Annonaceae / chemistry*
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Antineoplastic Agents, Phytogenic / toxicity*
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Cell Line, Tumor
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Cisplatin / toxicity
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Humans
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Inhibitory Concentration 50
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Plant Extracts / toxicity
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Plant Leaves / chemistry
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Polycyclic Aromatic Hydrocarbons / toxicity
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Sitosterols / toxicity*
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Toxicity Tests / methods
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Polycyclic Aromatic Hydrocarbons
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Sitosterols
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polycarpol
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gamma-sitosterol
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Cisplatin