Antineoplastic activity of selected constituents of Duguetia glabriuscula

Fitoterapia. 2006 Apr;77(3):227-9. doi: 10.1016/j.fitote.2006.01.013. Epub 2006 Mar 6.

Abstract

The cytotoxic effects of seven constituents isolated from Duguetia glabriuscula were evaluated against Hep2 human larynx carcinoma cells. The cytotoxicity exhibited by beta-sitosterol was as strong as that of cis-platin. (+)-Alloaromadendran-10,14beta-diol caused inhibition of cellular growth with IC50 values lower than 25 microg/ml, a feature that was considered as revealing significant activity. Polycarpol showed borderline cytotoxicity, whereas the other compounds were inactive.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Annonaceae / chemistry*
  • Antineoplastic Agents, Phytogenic / toxicity*
  • Cell Line, Tumor
  • Cisplatin / toxicity
  • Humans
  • Inhibitory Concentration 50
  • Plant Bark / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / toxicity
  • Plant Leaves / chemistry
  • Polycyclic Aromatic Hydrocarbons / toxicity
  • Sitosterols / toxicity*
  • Toxicity Tests / methods

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Polycyclic Aromatic Hydrocarbons
  • Sitosterols
  • polycarpol
  • gamma-sitosterol
  • Cisplatin