Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5. doi: 10.1016/j.bmcl.2006.03.020. Epub 2006 Mar 24.

Abstract

High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4.

MeSH terms

  • Alkylation
  • Amides / chemistry
  • Benzimidazoles / chemistry
  • Cross-Linking Reagents / chemistry
  • Interleukin-1 Receptor-Associated Kinases
  • Intracellular Signaling Peptides and Proteins / antagonists & inhibitors*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Molecular Structure
  • Protein Kinase Inhibitors / chemistry*
  • Protein Kinase Inhibitors / pharmacology*
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Structure-Activity Relationship

Substances

  • Amides
  • Benzimidazoles
  • Cross-Linking Reagents
  • Intracellular Signaling Peptides and Proteins
  • Protein Kinase Inhibitors
  • benzimidazole
  • Interleukin-1 Receptor-Associated Kinases
  • Protein-Serine-Threonine Kinases