Stem cells and cancer: two faces of eve

Cell. 2006 Mar 24;124(6):1111-5. doi: 10.1016/j.cell.2006.03.011.


Recent evidence suggests that a subset of cancer cells within some tumors, the so-called cancer stem cells, may drive the growth and metastasis of these tumors. Understanding the pathways that regulate proliferation, self-renewal, survival, and differentiation of malignant and normal stem cells may shed light on mechanisms that lead to cancer and suggest better modes of treatment.

MeSH terms

  • Cell Differentiation
  • Cell Proliferation
  • Humans
  • Neoplasm Metastasis / pathology*
  • Neoplasms / etiology
  • Neoplasms / pathology*
  • Neoplasms / prevention & control
  • Stem Cells*