Reply to "The role of soluble interleukin-6 receptor in inflammatory diseases" [Immunol Lett 2005;98(1):171]

Maria Michalopoulou; Chryssoula Nikolaou; Stylianos Chatzipanagiotou; Catherine Cambouri; Antonios Tavernarakis; Nectaria-Malamatina Alexandri; Michael Rentzos; Dimitrios Vassilopoulos

doi:10.1016/j.imlet.2006.01.008

Reply to "The role of soluble interleukin-6 receptor in inflammatory diseases" [Immunol Lett 2005;98(1):171]

Immunol Lett. 2006 May 15;105(1):99. doi: 10.1016/j.imlet.2006.01.008. Epub 2006 Feb 20.

Authors

Maria Michalopoulou, Chryssoula Nikolaou, Stylianos Chatzipanagiotou, Catherine Cambouri, Antonios Tavernarakis, Nectaria-Malamatina Alexandri, Michael Rentzos, Dimitrios Vassilopoulos

PMID: 16564095
DOI: 10.1016/j.imlet.2006.01.008

Abstract

We agree with the comments of Mr. Maggio and colleagues. The exact role of serum IL-6R and the relation between this and the IL-6/sIL-6R complex in inflammatory disorders has not been completely clarified. We suggest a discrepancy between sIL-6R concentrations and measurable IL-6/sIL-6R complex, not excluding the positive contribution of sIL-6R as a marker of neuro-immunoregulatory and inflammatory status in the central nervous system.

Publication types

Comment
Letter

MeSH terms

Humans
Inflammation / blood
Inflammation / immunology*
Interleukin-6 / blood
Receptors, Interleukin-6 / blood*
Solubility

Substances

Interleukin-6
Receptors, Interleukin-6